Weight-Loss Supplements Contain Dangerous Stimulants Years After Being Prohibited.

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▼ Some sports and weight-loss supplementsstill contain experimental stimulant drugs that were prohibited years ago by the U.S. Food and Drug Administration (FDA), according to a new study.
The study, published today (Oct. 22) in the journal JAMA Internal Medicine, analyzed 12 brands of sports and weight-loss supplements, looking for four potentially dangerous stimulant drugs that have popped up in recent years. The FDA has explicitly prohibited these drugs in supplements.undefined
The new findings show that "what the FDA is doing to try to eliminate experimental stimulants from supplements is not working," said lead study author Dr. Pieter Cohen, a general internist at Cambridge Health Alliance in Somerville, Massachusetts.
The prohibited drugs in the study are similar to amphetamines and include DMAA, an ingredient that the FDA warned in 2013could increase the risk of heart problems; DMBA, a stimulant that's very similar to DMAA; BMPEA, which is nearly identical in structure to the drug amphetamine; and oxilofrine, a stimulant that's banned in professional sports by the World Anti-Doping Agency.
In 2014, all 12 brands of supplements examined in the study tested positive for at least one of the four stimulants. The researchers then reanalyzed the supplements in 2017, after the FDA had prohibited the stimulants. (DMAA was prohibited in 2013; DMBA and BMPEA were prohibited in 2015, and oxilofrine in 2016.)
The investigators found that the number of brands containing the stimulants had decreased, but 9 out of 12 supplements (75 percent) still had at least one of the stimulants, and six supplements (50 percent) had at least two of the stimulants. Oxilofrine was the most common of the stimulants, found in nine of the supplements; DMBA was found in four supplements, and DMAA was found in two supplements — four years after the FDA prohibited the ingredient and warned of its dangers. BMPEA was also found in one supplement.  (▪ ▪ ▪)

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